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DNA Repair

The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.

Year introduced: 1974(1971)

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Subheadings:

Tree Number(s): G02.111.222, G05.219

MeSH Unique ID: D004260

Entry Terms:

  • Excision Repair
  • Excision Repairs
  • Repair, Excision
  • Nucleotide Excision Repair
  • Excision Repair, Nucleotide
  • Nucleotide Excision Repairs
  • Base Excision Repair
  • Base Excision Repairs
  • Excision Repair, Base
  • Repair, Base Excision
  • Repairs, Base Excision

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