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DNA Probes

Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.

Year introduced: 1989

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Tree Number(s): D13.444.600.223, D27.505.259.750.600.223, D27.720.470.530.600.223

MeSH Unique ID: D015342

Entry Terms:

  • Probes, DNA
  • DNA Hybridization Probes
  • Hybridization Probes, DNA
  • Probes, DNA Hybridization
  • Whole Genomic DNA Probes
  • Gene Probes, DNA
  • DNA Gene Probes
  • Probes, DNA Gene
  • Whole Chromosomal Probes
  • Chromosomal Probes, Whole
  • Probes, Whole Chromosomal
  • Chromosomal Probes
  • Probes, Chromosomal
  • Conserved Gene Probes
  • Gene Probes, Conserved
  • Probes, Conserved Gene

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