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DNA Modification Methylases

Enzymes that are part of the restriction-modification systems. They are responsible for producing a species-characteristic methylation pattern, on either adenine or cytosine residues, in a specific short base sequence in the host cell's own DNA. This methylated sequence will occur many times in the host-cell DNA and remain intact for the lifetime of the cell. Any DNA from another species which gains entry into a living cell and lacks the characteristic methylation pattern will be recognized by the restriction endonucleases of similar specificity and destroyed by cleavage. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms.

Year introduced: 1989

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Subheadings:

Tree Number(s): D08.811.150.240, D08.811.913.555.500.350

MeSH Unique ID: D015254

Registry Number: EC 2.1.1.-

Entry Terms:

  • Methylases, DNA Modification
  • Modification Methylases, DNA
  • Modification Methylases
  • Methylases, Modification
  • DNA Modification Methyltransferases
  • Methyltransferases, DNA Modification
  • Modification Methyltransferases, DNA

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