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Cytochrome P-450 Enzyme System

A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.

Year introduced: 1973

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Subheadings:

Tree Number(s): D08.244.453, D08.811.682.690.708.170, D12.776.422.220.453

MeSH Unique ID: D003577

Registry Number: 9035-51-2

Entry Terms:

  • Cytochrome P 450 Enzyme System
  • Cytochrome P450
  • P-450 Enzymes
  • Enzymes, P-450
  • P 450 Enzymes
  • P450 Enzymes
  • Enzymes, P450
  • CYP450 Family
  • Cytochrome P450 Superfamily
  • Superfamily, Cytochrome P450
  • Cytochrome P-450 Superfamily
  • Cytochrome P 450 Superfamily
  • Superfamily, Cytochrome P-450
  • Cytochrome p450 Families
  • Cytochrome P-450 Families
  • Cytochrome P 450 Families
  • CYP450 Superfamily
  • Superfamily, CYP450
  • Cytochrome P-450
  • Cytochrome P 450
  • Cytochrome P-450 Enzymes
  • Cytochrome P 450 Enzymes
  • Enzymes, Cytochrome P-450
  • P-450 Enzymes, Cytochrome
  • Cytochrome P-450 Monooxygenase
  • Cytochrome P 450 Monooxygenase
  • Monooxygenase, Cytochrome P-450
  • Cytochrome P-450-Dependent Monooxygenase
  • Cytochrome P 450 Dependent Monooxygenase
  • Monooxygenase, Cytochrome P-450-Dependent
  • Cytochrome P-450 Oxygenase
  • Cytochrome P 450 Oxygenase

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