Cytochalasin D

A fungal metabolite that blocks cytoplasmic cleavage by blocking formation of contractile microfilament structures resulting in multinucleated cell formation, reversible inhibition of cell movement, and the induction of cellular extrusion. Additional reported effects include the inhibition of actin polymerization, DNA synthesis, sperm motility, glucose transport, thyroid secretion, and growth hormone release.

Year introduced: 1990

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Tree Number(s): D03.633.100.473.231.450, D23.946.587.370.450

MeSH Unique ID: D015638

Registry Number: 22144-77-0

Previous Indexing:

• Cytochalasins (1973-1989)

Pharmacologic Action:

• Nucleic Acid Synthesis Inhibitors

All MeSH Categories
Chemicals and Drugs Category
Heterocyclic Compounds
Heterocyclic Compounds, Fused-Ring
Heterocyclic Compounds, 2-Ring
Indoles
Cytochalasins
Cytochalasin D

All MeSH Categories
Chemicals and Drugs Category
Biological Factors
Toxins, Biological
Mycotoxins
Cytochalasins
Cytochalasin D