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Complement Factor I

A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.

Year introduced: 1993

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Tree Number(s): D08.811.277.656.300.760.210, D08.811.277.656.959.350.210, D12.776.124.486.274.920.325.210

MeSH Unique ID: D017244

Registry Number: EC 3.4.21.45

Entry Terms:

  • C4b-C3b-INA
  • C4b C3b INA
  • C3b Inactivator
  • Inactivator, C3b
  • C4bC3bINA
  • Complement C4b-C3b Inactivator
  • C4b-C3b Inactivator, Complement
  • Complement C4b C3b Inactivator
  • Inactivator, Complement C4b-C3b
  • C3b-C4b Inactivator
  • C3b C4b Inactivator
  • Inactivator, C3b-C4b
  • Complement 3b-Complement 4b Inactivator
  • Complement 3b Complement 4b Inactivator

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