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Complement C3b

The larger fragment generated from the cleavage of COMPLEMENT C3 by C3 CONVERTASE. It is a constituent of the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb), and COMPLEMENT C5 CONVERTASES in both the classical (C4b2a3b) and the alternative (C3bBb3b) pathway. C3b participates in IMMUNE ADHERENCE REACTION and enhances PHAGOCYTOSIS. It can be inactivated (iC3b) or cleaved by various proteases to yield fragments such as COMPLEMENT C3C; COMPLEMENT C3D; C3e; C3f; and C3g.

Year introduced: 2006 (1978)

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Subheadings:

Tree Number(s): D12.776.124.486.274.250.260

MeSH Unique ID: D003179

Registry Number: 80295-43-8

Entry Terms:

  • C3b, Complement
  • Complement Component 3b
  • Component 3b, Complement
  • C3b Complement
  • Complement, C3b
  • Complement 3b
  • Inactivated C3b
  • C3b, Inactivated
  • iC3b
  • C3bi

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