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Complement C1

The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.

Year introduced: 2006 (1975)

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Subheadings:

Tree Number(s): D12.776.124.486.274.050

MeSH Unique ID: D003172

Entry Terms:

  • C1, Complement
  • C1 Complement
  • Complement, C1
  • Complement 1
  • Complement Component 1
  • Component 1, Complement

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