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Colorectal Neoplasms, Hereditary Nonpolyposis

A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.

Year introduced: 1987

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Tree Number(s): C04.588.274.476.411.307.190, C04.700.250, C06.301.371.411.307.190, C06.405.249.411.307.190, C06.405.469.158.356.190, C06.405.469.491.307.190, C16.320.700.250, C18.452.284.255

MeSH Unique ID: D003123

Entry Terms:

  • Familial Nonpolyposis Colon Cancer
  • Hereditary Nonpolyposis Colorectal Neoplasms
  • Lynch Syndrome
  • Syndrome, Lynch
  • Lynch Syndrome I
  • Lynch Cancer Family Syndrome I
  • Hereditary Nonpolyposis Colorectal Cancer
  • Colorectal Cancer Hereditary Nonpolyposis
  • Hereditary Nonpolyposis Colon Cancer
  • Colon Cancer, Familial Nonpolyposis

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