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Cholera Toxin

An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.

Year introduced: 1978

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Subheadings:

Tree Number(s): D08.811.913.400.725.115.180, D23.946.123.194, D23.946.330.150

MeSH Unique ID: D002772

Registry Number: 9012-63-9

Entry Terms:

  • Toxin, Cholera
  • Cholera Exotoxin
  • Exotoxin, Cholera
  • Choleragen
  • Cholera Enterotoxin CT
  • CT, Cholera Enterotoxin
  • Enterotoxin CT, Cholera
  • Choleragenoid
  • Cholera Toxin Protomer B
  • Cholera Toxin B Subunit
  • Procholeragenoid
  • Cholera Toxin Protomer A
  • Cholera Toxin A Subunit

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