Cathepsin C
A papain-like cysteine protease that has specificity for amino terminal dipeptides. The enzyme plays a role in the activation of several pro-inflammatory serine proteases by removal of their aminoterminal inhibitory dipeptides. Genetic mutations that cause loss of cathepsin C activity in humans are associated with PAPILLON-LEFEVRE DISEASE.
Year introduced: 2010(1981)
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Subheadings:
Tree Number(s): D08.811.277.656.224.130, D08.811.277.656.262.186, D08.811.277.656.350.350.100
MeSH Unique ID: D020789
Registry Number: EC 3.4.14.1
Entry Terms:
- Dipeptidyl Aminopeptidase I
- Dipeptidyl Peptidase I
- Dipeptidyl Transferase
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