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Caspases, Initiator

A subtype of caspases that contain long pro-domain regions that regulate the activation of the enzyme. The pro-domain regions contain protein-protein interaction motifs that can interact with specific signaling adaptor proteins such as DEATH DOMAIN RECEPTORS; DED SIGNALING ADAPTOR PROTEINS; and CARD SIGNALING ADAPTOR PROTEINS. Once activated, the initiator caspases can activate other caspases such as the EFFECTOR CASPASES.

Year introduced: 2007

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Tree Number(s): D08.811.277.656.262.500.126.550, D08.811.277.656.300.200.126.550, D12.644.360.075.405.550, D12.776.476.075.405.550

MeSH Unique ID: D053471

Registry Number: EC 3.4.22.-

Entry Terms:

  • Initiator Caspases

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