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Caspase 8

A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.

Year introduced: 2007(2000)

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Tree Number(s): D08.811.277.656.262.500.126.550.800, D08.811.277.656.300.200.126.550.800, D12.776., D12.776.476.024.320.025, D12.776.476.075.405.550.800, D12.776.476.075.421.037

MeSH Unique ID: D053181

Registry Number: EC 3.4.22.-

Entry Terms:

  • Caspase-8
  • MACH Protein
  • Mch5 Protease
  • CAP4 Protease
  • FLICE Protein
  • Procaspase-8
  • Procaspase 8
  • Pro-Caspase-8
  • Pro Caspase 8

See Also:

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