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Caspase 2

A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.

Year introduced: 2007(1994)

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Tree Number(s): D08.811.277.656.262.500.126.550.200, D08.811.277.656.300.200.126.550.200, D12.644.360.075.405.550.200, D12.776.476.075.405.550.200

MeSH Unique ID: D053143

Registry Number: EC 3.4.22.-

Entry Terms:

  • ICH-1 Protease
  • ICH 1 Protease
  • Caspase-2
  • Procaspase-2
  • Procaspase 2
  • Pro-Caspase-2
  • Pro Caspase 2
  • Caspase 2 Subunit p18
  • Caspase 2 Subunit p12
  • Caspase 2 Subunit p13

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