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Caspase 12

A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 12 is activated by pro-apoptotic factors that are released during cell stress and by CARD SIGNALING ADAPTOR PROTEINS. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.

Year introduced: 2007(2000)

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Tree Number(s): D08.811.277.656.262.500.126.550.920, D08.811.277.656.300.200.126.550.920, D12.644.360.075.405.550.920, D12.776.476.075.405.550.920

MeSH Unique ID: D053454

Registry Number: EC 3.4.22.-

Entry Terms:

  • Caspase-12

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