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Calreticulin

A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.

Year introduced: 2003

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Subheadings:

Tree Number(s): D12.644.360.372.374, D12.776.157.125.412.374, D12.776.476.387.374, D12.776.503.303

MeSH Unique ID: D037282

Entry Terms:

  • CAB-63
  • CBP3 (Liver)
  • ERp60
  • cC1qR Protein
  • Calcium-Binding Protein-3
  • Calcium Binding Protein 3
  • Calregulin
  • 55-kDa High-Affinity Calcium Binding Protein
  • 55 kDa High Affinity Calcium Binding Protein
  • HACBP

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