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Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC

Year introduced: 1986

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Tree Number(s): D08.811.277.656.262.500.120, D08.811.277.656.300.200.120

MeSH Unique ID: D002154

Registry Number: EC 3.4.22.-

Entry Terms:

  • Calcium-Activated Protease
  • Calcium Activated Protease
  • Protease, Calcium-Activated
  • Calcium-Dependent Neutral Proteinase
  • Calcium Dependent Neutral Proteinase
  • Neutral Proteinase, Calcium-Dependent
  • Proteinase, Calcium-Dependent Neutral
  • Desminase
  • Ca2+-Activated Protease
  • Ca2+ Activated Protease
  • Protease, Ca2+-Activated
  • Calcium-Activated Neutral Proteinase
  • Calcium Activated Neutral Proteinase
  • Neutral Proteinase, Calcium-Activated
  • Proteinase, Calcium-Activated Neutral
  • Calcium-Activated Neutral Protease
  • Calcium Activated Neutral Protease
  • Neutral Protease, Calcium-Activated
  • Protease, Calcium-Activated Neutral
  • Calcium-Dependent Neutral Protease
  • Calcium Dependent Neutral Protease
  • Neutral Protease, Calcium-Dependent
  • Protease, Calcium-Dependent Neutral
  • Calpain I
  • Calpain II

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