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Aryl Hydrocarbon Hydroxylases

A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.

Year introduced: 1975

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Subheadings:

Tree Number(s): D08.244.453.005, D08.811.682.690.708.170.010, D12.776.422.220.453.010

MeSH Unique ID: D001189

Registry Number: EC 1.14.14.1

Entry Terms:

  • Hydroxylases, Aryl Hydrocarbon
  • Microsomal Monooxygenases
  • Monooxygenases, Microsomal
  • Xenobiotic Monooxygenases
  • Monooxygenases, Xenobiotic

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