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Aromatase

An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.

Year introduced: 1986(1975)

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Tree Number(s): D08.244.453.489.500, D08.244.453.915.099, D08.811.682.690.708.170.447.500, D08.811.682.690.708.170.915.099, D12.776.422.220.453.489.500, D12.776.422.220.453.915.099

MeSH Unique ID: D001141

Registry Number: EC 1.14.14.1

Entry Terms:

  • Estrogen Synthetase
  • Estrogen Synthase
  • Cytochrome P450 19
  • CYP19 Protein
  • Protein, CYP19
  • Cytochrome P-450(AROM)
  • CYP 19
  • Cytochrome P-450 CYP19
  • Cytochrome P 450 CYP19
  • P450AROM
  • Androstenedione Aromatase
  • Aromatase, Androstenedione
  • CYP19

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