Apoptotic Protease-Activating Factor 1
A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal WD40 REPEATS. It plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY) and binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX which activates INITIATOR CASPASES such as CASPASE 9.
Year introduced: 2007(1997)
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Subheadings:
Tree Number(s): D12.644.360.024.131.124, D12.644.360.075.358.124, D12.776.157.057.006.124, D12.776.476.024.139.124, D12.776.476.075.358.124
MeSH Unique ID: D053477
Entry Terms:
- Apoptotic Protease Activating Factor 1
- Apoptotic Peptidase Activating Factor 1
- Apaf-1 Protease-Activating Factor
- Apaf 1 Protease Activating Factor
- Protease-Activating Factor, Apaf-1