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A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

Year introduced: 1993

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Tree Number(s): G04.146.954.035

MeSH Unique ID: D017209

Entry Terms:

  • Classic Apoptosis
  • Apoptosis, Classic
  • Classic Apoptoses
  • Programmed Cell Death, Type I
  • Classical Apoptosis
  • Apoptosis, Classical
  • Apoptosis, Intrinsic Pathway
  • Apoptoses, Intrinsic Pathway
  • Intrinsic Pathway Apoptoses
  • Intrinsic Pathway Apoptosis
  • Apoptosis, Extrinsic Pathway
  • Apoptoses, Extrinsic Pathway
  • Extrinsic Pathway Apoptoses
  • Extrinsic Pathway Apoptosis
  • Caspase-Dependent Apoptosis
  • Apoptosis, Caspase-Dependent
  • Caspase Dependent Apoptosis
  • Programmed Cell Death
  • Cell Death, Programmed

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