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Apolipoprotein E4

A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.

Year introduced: 2007 (1982)

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Subheadings:

Tree Number(s): D10.532.091.500.750, D12.776.070.400.500.750, D12.776.521.120.500.750

MeSH Unique ID: D053327

Entry Terms:

  • Apolipoprotein E-4
  • Apolipoprotein E 4
  • Apo E4
  • ApoE4
  • Apo E epsilon 4
  • Apo E-4
  • Apo E 4

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