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Apolipoprotein E2

One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.

Year introduced: 2007 (1984)

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Subheadings:

Tree Number(s): D10.532.091.500.249, D12.776.070.400.500.249, D12.776.521.120.500.249

MeSH Unique ID: D053329

Entry Terms:

  • ApoE2
  • Apolipoprotein E-2
  • Apolipoprotein E 2
  • Apolipoprotein E-epsilon2
  • Apolipoprotein E epsilon2
  • Apo E-2
  • Apo E 2
  • Apo E2
  • APOE-epsilon2
  • APOE epsilon2
  • APOE-epsilon 2
  • APOE epsilon 2

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