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fas Receptor

A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome.

Year introduced: 2018 (1989)

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Subheadings:

Tree Number(s): D12.776.543.750.690.500, D12.776.543.750.705.852.760.195

MeSH Unique ID: D019014

Entry Terms:

  • Receptor, fas
  • fas Antigen
  • fas Antigens
  • APO-1 Antigen
  • APO 1 Antigen
  • CD95 Antigen
  • TNFRSF6 Receptor
  • Receptor, TNFRSF6
  • Antigens, CD95
  • Receptors, fas
  • fas Receptors
  • Tumor Necrosis Factor Receptor Superfamily, Member 6
  • Fas Cell Surface Death Receptor
  • CD95 Antigens

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