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Activating Transcription Factor 6

One of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response.

Year introduced: 2006(1997)

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Subheadings:

Tree Number(s): D12.644.360.011, D12.776.260.108.061.968, D12.776.476.011, D12.776.930.127.061.968

MeSH Unique ID: D051702

Entry Terms:

  • ATF6 Transcription Factor
  • Transcription Factor, ATF6

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