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1.

Translocation, Genetic

A type of chromosome aberration characterized by CHROMOSOME BREAKAGE and transfer of the broken-off portion to another location, often to a different chromosome.

Year introduced: 2005(1968)

2.

Protein Transport

The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.

Year introduced: 2001

3.

Bacterial Translocation

The passage of viable bacteria from the GASTROINTESTINAL TRACT to extra-intestinal sites, such as the mesenteric lymph node complex, liver, spleen, kidney, and blood. Factors that promote bacterial translocation include overgrowth with gram-negative enteric bacilli, impaired host immune defenses, and injury to the INTESTINAL MUCOSA resulting in increased intestinal permeability. Bacterial translocation from the lung to the circulation is also possible and sometimes accompanies MECHANICAL VENTILATION.

Year introduced: 1996

4.

RUNX1 Translocation Partner 1 Protein

A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis.

Year introduced: 2018

5.

Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein

A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity. It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA B; it also binds to and activates TRAF6. Chromosomal translocations involving the MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1 gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES.

Year introduced: 2018

6.

SEC Translocation Channels

Universally conserved multiprotein complexes that form the protein transport channel of the general secretory (SEC) pathway. The SEC translocase is present in all bacteria, archaea, and eukaryotes. It is in the ENDOPLASMIC RETICULUM membrane of eukaryotic cells, in the THYLAKOID MEMBRANE in CHLOROPLASTS and in some protozoa in the INNER MITOCHONDRIAL MEMBRANE.

Year introduced: 2017

7.

Twin-Arginine-Translocation System

Protein translocase in BACTERIA or CHLOROPLASTS that exports or secretes folded proteins. In GRAM-NEGATIVE BACTERIA, twin-arginine translocase (TAT) is involved in the export of folded proteins to the PERIPLASM. In chloroplasts, TAT is involved in transporting folded proteins across the membranes of THYLAKOIDS.

Year introduced: 2016

8.

Protein Translocation Systems

Multiprotein complexes that carry out PROTEIN TRANSPORT across CELL MEMBRANES.

Year introduced: 2016

9.

receptor macromolecular translocation inhibitor [Supplementary Concept]

inhibit the binding of activated steroid-receptor complexes to nuclei, chromatin or DNA; do not confuse with receptor translocation modulator which converts the receptor-steroid complex to activated receptor-steroid complex

Date introduced: November 20, 1980

10.

Btg1 protein, rat [Supplementary Concept]

RefSeq NM_017258

Date introduced: September 29, 2004

11.

Btg1 protein, mouse [Supplementary Concept]

RefSeq NM_007569

Date introduced: September 29, 2004

12.

twin-arginine translocase complex, E coli [Supplementary Concept]

involved in bacterial translocation of proteins across the cytoplasmic membrane; it is composed of TatA, TatB, TatC and TatE components; do not confuse with either tat gene product from HIV (Gene Products, tat) or tat protein

Date introduced: June 1, 2000

13.

MALT1 protein, human [Supplementary Concept]

RefSeq NM_006785

Date introduced: November 17, 1999

14.

CBFA2T3 protein, human [Supplementary Concept]

RefSeq NM_005187

Date introduced: December 4, 1998

15.

ETS translocation variant 6 protein [Supplementary Concept]

tel - translocation, Ets, leukemia; a novel ets-like gene product; tel fused with the tyrosine kinase domain of the platelet-derived growth factor receptor beta results to a translocation characteristic of chronic myelomonocytic leukemia (CMML); gene tel was renamed ETV6; RefSeq NM_001987 (human), NM_007961 (mouse)

Date introduced: May 31, 1994

16.

BTG1 protein, human [Supplementary Concept]

RefSeq NM_001731

Date introduced: May 14, 1992

17.

TET3 protein, Xenopus [Supplementary Concept]

RefSeq NM_001097187

Date introduced: February 4, 2013

18.

111In-nuclear translocation sequence-7G3 [Supplementary Concept]

an Auger electron-emitting radioimmunotherapeutic agent derived from monoclonal antibody 7G3 that is modified with peptides containing the nuclear translocation sequence of SV-40 large T-antigen

Date introduced: October 30, 2011

19.

Tet2 protein, mouse [Supplementary Concept]

RefSeq NM_001040400

Date introduced: September 7, 2010

20.
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