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1.

Oxytocin

A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.

Year introduced: ALPHA-HYPOPHAMINE was see OXYTOCIN 1977-1993

2.

Receptors, Oxytocin

Cell surface proteins that bind oxytocin with high affinity and trigger intracellular changes which influence the behavior of cells. Oxytocin receptors in the uterus and the mammary glands mediate the hormone's stimulation of contraction and milk ejection. The presence of oxytocin and oxytocin receptors in neurons of the brain probably reflects an additional role as a neurotransmitter.

Year introduced: 1994

3.

oxytocin, Gly-Lys-Arg- [Supplementary Concept]

Date introduced: September 24, 1985

4.

oxytocin, 1-penicillamyl-O-MeTyr(2)- [Supplementary Concept]

RN given refers to (D-Val-L-Tyr)-isomer

Date introduced: December 5, 1984

6.

atosiban [Supplementary Concept]

Date introduced: December 9, 1985

7.

oxytocin, Thr(4)-Gly(7)- [Supplementary Concept]

RN given refers to parent cpd

Date introduced: June 19, 1985

8.

oxytocin, (1-(2-hydroxy-3-mercaptopropionic acid))-Thr(4)-Gly(7)- [Supplementary Concept]

RN given refers to parent cpd(R)-isomer

Date introduced: August 2, 1984

9.

oxytocin, (4-ethyl-Phe)(2)- [Supplementary Concept]

RN given refers to cpd without isomeric designation

Date introduced: August 22, 1983

10.
11.

oxytocin, 1,6-alpha-Asu- [Supplementary Concept]

Date introduced: January 1, 1976

12.

oxytocin, N-acetyl-2-O-methyl-Tyr- [Supplementary Concept]

specific antagonist of oxytocin; an oxytocin receptor antagonist

Date introduced: January 1, 1974

13.

mesotocin [Supplementary Concept]

Date introduced: January 1, 1972

14.

ANTAG III [Supplementary Concept]

Date introduced: December 11, 1998

15.

ANTAG II [Supplementary Concept]

Date introduced: December 11, 1998

16.

ANTAG I [Supplementary Concept]

Date introduced: December 11, 1998

17.

oxytocin, 1-d(CH2)5-(2-O-methyl)Tyr-Thr(4)-Orn(8)-Tyr-NH2(9)- [Supplementary Concept]

oxytocin receptor ligand

Date introduced: September 27, 1996

18.

oxytocin, Hmp(1)-Phe(2)-Hgn(4)-Dab(Ala)(8)- [Supplementary Concept]

a vasopressin V1 receptor agonist; names for amino acids which are abbreviated Hmp & Hgn not known

Date introduced: July 8, 1993

19.

oxytocin, Pmp(1)-Trp(2)-Cys(6)-Arg(8)- [Supplementary Concept]

an oxytocin antagonist

Date introduced: April 26, 1993

20.

oxytocin, 3,2'-di-Me-Phe(2)- [Supplementary Concept]

an oxytocin antagonist

Date introduced: December 26, 1992

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