nonsense - MeSH - NCBI

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Items: 20

Select item 680183891.

Codon, Nonsense

An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.

Year introduced: 1995

Select item 680593652.

Nonsense Mediated mRNA Decay

An mRNA metabolic process that distinguishes a normal STOP CODON from a premature stop codon (NONSENSE CODON) and facilitates rapid degradation of aberrant mRNAs containing premature stop codons.

Year introduced: 2012

Select item 680161533.

Genes, Suppressor

Genes that have a suppressor allele or suppressor mutation (SUPPRESSION, GENETIC) which cancels the effect of a previous mutation, enabling the wild-type phenotype to be maintained or partially restored. For example, amber suppressors cancel the effect of an AMBER NONSENSE MUTATION.

Year introduced: 1991

Select item 674682864.

UPF2 protein, human [Supplementary Concept]

RefSeq NM_015542

Date introduced: November 23, 2002

Select item 21069775.

Smg7 protein, mouse [Supplementary Concept]

RefSeq XM_006529450

Date introduced: September 15, 2023

Select item 675857756.

UPF3B protein, mouse [Supplementary Concept]

Date introduced: January 21, 2014

Select item 675559387.

SMG8 protein, human [Supplementary Concept]

RefSeq NM_018149

Date introduced: February 16, 2011

Select item 675337838.

SMG7 protein, Arabidopsis [Supplementary Concept]

has an evolutionarily conserved role in nonsense-mediated RNA decay and required for exit from meiosis; has been sequenced

Date introduced: December 18, 2008

Select item 675158019.

SMG5 protein, human [Supplementary Concept]

RefSeq NM_015327

Date introduced: January 1, 2007

Select item 6751226110.

SMG6 protein, human [Supplementary Concept]

RefSeq NM_017575

Date introduced: August 6, 2006

Select item 6749457811.

SMG7 protein, human [Supplementary Concept]

acts as a molecular link between mRNA surveillance and mRNA decay, RefSeq NM_014837

Date introduced: December 30, 2004

Select item 6748444612.

Rent1 protein, mouse [Supplementary Concept]

contains zinc fingers and NTPase domains; RefSeq NM_030680

Date introduced: August 6, 2004

Select item 6743548813.

UPF3B protein, human [Supplementary Concept]

RefSeq NM_023010

Date introduced: September 25, 2001

Select item 6743548714.

UPF3A protein, human [Supplementary Concept]

RefSeq NM_023011

Date introduced: September 25, 2001

Select item 6710182815.

UPF1 protein, human [Supplementary Concept]

RefSeq NM_002911

Date introduced: November 18, 1996

Select item 210188116.

Smg6 protein, mouse [Supplementary Concept]

RefSeq NM_001002764

Date introduced: January 28, 2022

Select item 210007417.

Smg1 protein, rat [Supplementary Concept]

RefSeq XM_002725659

Date introduced: May 11, 2021

Select item 205027618.

SMG9 protein, human [Supplementary Concept]

RefSeq NM_019108

Date introduced: February 24, 2020

Select item 202246219.

UPF1 protein, rat [Supplementary Concept]

RefSeq XM_003751566

Date introduced: October 3, 2017

Select item 201504720.

UPF 3A protein, mouse [Supplementary Concept]

RefSeq NM_025924

Date introduced: August 30, 2016

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