MeSH

An amino acid-specifying codon that has been converted to a stop codon (CODON, TERMINATOR) by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.

Year introduced: 1995

An mRNA metabolic process that distinguishes a normal STOP CODON from a premature stop codon (NONSENSE CODON) and facilitates rapid degradation of aberrant mRNAs containing premature stop codons.

Year introduced: 2012

Genes that have a suppressor allele or suppressor mutation (SUPPRESSION, GENETIC) which cancels the effect of a previous mutation, enabling the wild-type phenotype to be maintained or partially restored. For example, amber suppressors cancel the effect of an AMBER NONSENSE MUTATION.

Year introduced: 1991

RefSeq NM_015542

RefSeq XM_006529450

RefSeq NM_018149

has an evolutionarily conserved role in nonsense-mediated RNA decay and required for exit from meiosis; has been sequenced

RefSeq NM_015327

RefSeq NM_017575

acts as a molecular link between mRNA surveillance and mRNA decay, RefSeq NM_014837

contains zinc fingers and NTPase domains; RefSeq NM_030680

RefSeq NM_023010

RefSeq NM_023011

RefSeq NM_002911

Gene ID: 562557

RefSeq NM_001002764

RefSeq XM_002725659

RefSeq NM_019108

RefSeq XM_003751566