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1.

Prostate

A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.

2.

Transurethral Resection of Prostate

Removal of all or part of the PROSTATE, often using a cystoscope and/or resectoscope passed through the URETHRA.

Year introduced: 2000

3.

Prostate-Specific Antigen

A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.

Year introduced: 1993

4.

Prostatic Neoplasms

Tumors or cancer of the PROSTATE.

5.

prostate apoptosis response-4 protein [Supplementary Concept]

induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C; do not confuse with protease-activated receptor 4; RefSeq NM_002583 (human); XM_125814 (mouse); NM_033485 (rat)

Date introduced: October 15, 1996

6.

STEAP2 protein, human [Supplementary Concept]

RefSeq NM_152999

Date introduced: November 11, 2002

7.

Tissue Kallikreins

A family of trypsin-like SERINE ENDOPEPTIDASES that are expressed in a variety of cell types including human prostate epithelial cells. They are formed from tissue prokallikrein by action with TRYPSIN. They are highly similar to PROSTATE-SPECIFIC ANTIGEN.

Year introduced: 2000

8.

Prostate cancer, familial [Supplementary Concept]

Germline mutations in the RNASEL gene have been identified for an autosomal dominant form of hereditary prostate cancer (OMIM: 601518). Several other loci which confer susceptibility to prostate cancer have also been mapped. OMIM: 176807

Date introduced: August 25, 2010

9.
10.

Growth Differentiation Factor 15

A growth differentiation factor that is secreted in response to cell stress and in response to MACROPHAGE ACTIVATION. In addition growth differentiation factor 15 demonstrates a diverse array of biological properties including the induction of cartilage formation, the inhibition of hematopoietic progenitor proliferation, and the induction of neuronal migration.

Year introduced: 2009(1997)

11.

Clusterin

A highly conserved heterodimeric glycoprotein that is differentially expressed during many severe physiological disturbance states such as CANCER; APOPTOSIS; and various NEUROLOGICAL DISORDERS. Clusterin is ubiquitously expressed and appears to function as a secreted MOLECULAR CHAPERONE.

Year introduced: 2006(1980)

12.

Prostate Cancer, Hereditary, 8 [Supplementary Concept]

aka HPC8

Date introduced: November 5, 2012

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16.

Steap protein, mouse [Supplementary Concept]

six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen; RefSeq NM_027399

Date introduced: August 6, 2004

17.

FOLH1 protein, human [Supplementary Concept]

highly expressed in prostate epithelium, used as diagnostic tool, see also PROSTATE-SPECIFIC ANTIGEN; RefSeq NM_004476

Date introduced: September 2, 2003

18.

HPG-1 protein, human [Supplementary Concept]

127 amino acid residues, MW 14.8 kDa; the androgen-responsive gene HPG-1, has prostate-specific expression and seems to be involved in carcinogenesis; amino acid sequence in first source

Date introduced: March 12, 2003

19.

PATE1 protein, human [Supplementary Concept]

RefSeq NM_138294

Date introduced: April 25, 2002

20.

PCAT4 protein, human [Supplementary Concept]

a gene differentially expressed in normal prostate and prostate cancer; RefSeq NM_058168

Date introduced: October 3, 2001

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