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A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)


NBL1 protein, human [Supplementary Concept]

RefSeq NM_005380

Date introduced: September 29, 2004


Esthesioneuroblastoma, Olfactory

A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)

Year introduced: 2000(1994)



A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)


Nbl1 protein, mouse [Supplementary Concept]

may exhibit tumor-suppressive activity; RefSeq NM_008675

Date introduced: September 29, 2004


NBAS protein, human [Supplementary Concept]

NAG gene is co-amplified with N-myc gene in neuroblastoma; RefSeq NM_015909

Date introduced: February 25, 1999


Nbl1 protein, rat [Supplementary Concept]

may exhibit tumor-suppressive activity; RefSeq NM_031609

Date introduced: March 11, 1994


Nras protein, mouse [Supplementary Concept]

RefSeq NM_010937

Date introduced: February 20, 2014


smgl-1 protein, C elegans [Supplementary Concept]

RefSeq NM_001044807

Date introduced: November 12, 2013


NRAS protein, human [Supplementary Concept]

RefSeq NM_002524

Date introduced: April 18, 2013


MYCN protein, mouse [Supplementary Concept]

RefSeq NM_008709

Date introduced: May 3, 2012


NBAS protein, zebrafish [Supplementary Concept]

a nonsense-mediated mRNA decay (NMD) factor; RefSeq NM_001044807

Date introduced: July 28, 2011


NBPF3 protein, human [Supplementary Concept]

RefSeq NM_032264

Date introduced: July 18, 2007


FAM163A protein, human [Supplementary Concept]

RefSeq NM_173509

Date introduced: February 4, 2007


QSOX2 protein, human [Supplementary Concept]

RefSeq NM_181701

Date introduced: February 4, 2004


MYCN protein, human [Supplementary Concept]

RefSeq NM_005378

Date introduced: July 17, 2002


CELF2 protein, human [Supplementary Concept]

RefSeq NM_001025076

Date introduced: February 26, 1999


Mycn protein, rat [Supplementary Concept]

RefSeq NM_001013096

Date introduced: September 30, 2016

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