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Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
NBL1 protein, human [Supplementary Concept]
RefSeq NM_005380
Date introduced: September 29, 2004
Esthesioneuroblastoma, Olfactory
A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)
Year introduced: 2000(1994)
Retinoblastoma
A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
Nbl1 protein, mouse [Supplementary Concept]
may exhibit tumor-suppressive activity; RefSeq NM_008675
NBAS protein, human [Supplementary Concept]
NAG gene is co-amplified with N-myc gene in neuroblastoma; RefSeq NM_015909
Date introduced: February 25, 1999
Nbl1 protein, rat [Supplementary Concept]
may exhibit tumor-suppressive activity; RefSeq NM_031609
Date introduced: March 11, 1994
Nras protein, mouse [Supplementary Concept]
RefSeq NM_010937
Date introduced: February 20, 2014
smgl-1 protein, C elegans [Supplementary Concept]
RefSeq NM_001044807
Date introduced: November 12, 2013
NRAS protein, human [Supplementary Concept]
RefSeq NM_002524
Date introduced: April 18, 2013
MYCN protein, mouse [Supplementary Concept]
RefSeq NM_008709
Date introduced: May 3, 2012
NBAS protein, zebrafish [Supplementary Concept]
a nonsense-mediated mRNA decay (NMD) factor; RefSeq NM_001044807
Date introduced: July 28, 2011
Nav2 protein, mouse [Supplementary Concept]
Date introduced: May 7, 2010
Hirschsprung disease ganglioneuroblastoma [Supplementary Concept]
Date introduced: August 25, 2010
NBPF3 protein, human [Supplementary Concept]
RefSeq NM_032264
Date introduced: July 18, 2007
FAM163A protein, human [Supplementary Concept]
RefSeq NM_173509
Date introduced: February 4, 2007
QSOX2 protein, human [Supplementary Concept]
RefSeq NM_181701
Date introduced: February 4, 2004
MYCN protein, human [Supplementary Concept]
RefSeq NM_005378
Date introduced: July 17, 2002
CELF2 protein, human [Supplementary Concept]
RefSeq NM_001025076
Date introduced: February 26, 1999
Mycn protein, rat [Supplementary Concept]
RefSeq NM_001013096
Date introduced: September 30, 2016