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Solute Carrier Family 12, Member 3

Na-Cl cotransporter in the convoluted segments of the DISTAL KIDNEY TUBULE. It mediates active reabsorption of sodium and chloride and is inhibited by THIAZIDE DIURETICS.

Year introduced: 2014


Sodium Potassium Chloride Symporter Inhibitors

Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. They act as DIURETICS. Excess use is associated with HYPOKALEMIA and HYPERGLYCEMIA.

Year introduced: 2006


Atp1a2 protein, rat [Supplementary Concept]

RefSeq NM_012505

Date introduced: September 16, 2005


Solute Carrier Family 12, Member 1

Na-K-Cl transporter in the ASCENDING LIMB OF LOOP OF HENLE. It mediates active reabsorption of sodium chloride and is inhibited by LOOP DIURETICS such as FUROSEMIDE; and BUMETANIDE. Mutations in the gene encoding SLC12A1 are associated with a BARTTER SYNDROME.

Year introduced: 2014


Sodium-Potassium-Chloride Symporters

A subclass of symporters that specifically transport SODIUM CHLORIDE and/or POTASSIUM CHLORIDE across cellular membranes in a tightly coupled process.

Year introduced: 2002


Sodium-Hydrogen Exchangers

A family of plasma membrane exchange glycoprotein antiporters that transport sodium ions and protons across lipid bilayers. They have critical functions in intracellular pH regulation, cell volume regulation, and cellular response to many different hormones and mitogens.

Year introduced: 2018 (1994)


ATP1A1 protein, human [Supplementary Concept]

RefSeq NM_001001586

Date introduced: July 29, 2005


Sodium-Bicarbonate Symporters

Proteins that cotransport sodium ions and bicarbonate ions across cellular membranes.

Year introduced: 2002


Sodium-Calcium Exchanger

An electrogenic ion exchange protein that maintains a steady level of calcium by removing an amount of calcium equal to that which enters the cells. It is widely distributed in most excitable membranes, including the brain and heart.

Year introduced: 1998


sodium-bile acid cotransporter [Supplementary Concept]

amino acid sequence given in first source; GenBank U02028

Date introduced: January 7, 1992


CH 401-Na [Supplementary Concept]

RN given refers to mono-Na salt; structure

Date introduced: January 1, 1977


Sodium-Potassium-Exchanging ATPase

An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.

Year introduced: 2008(1978)


ATP1A3 protein, zebrafish [Supplementary Concept]

RefSeq NM_131684 (atp1a3a); RefSeq NM_131685 (atp1a3b)

Date introduced: May 29, 2013


Scn10a protein, mouse [Supplementary Concept]

RefSeq NM_001205321

Date introduced: August 24, 2012


ATP1B1 protein, human [Supplementary Concept]

RefSeq NM_001001787

Date introduced: September 16, 2005


V-type sodium ATPase, Enterococcus hirae [Supplementary Concept]

the membrane rotor ring consists of 10 NtpK subunits, which are homologs of the 16-kilodalton and 8-kilodalton proteolipids found in other V-ATPases and in F1Fo- or F-ATPases, respectively; amino acid sequence in first source

Date introduced: May 11, 2005


Atp1a1 protein, rat [Supplementary Concept]

RefSeq NM_012504

Date introduced: July 29, 2005


atp1a1a.1 protein, zebrafish [Supplementary Concept]

RefSeq NM_131686

Date introduced: November 16, 2001


atp1a1b protein, zebrafish [Supplementary Concept]

RefSeq: NM_131690

Date introduced: November 16, 2001

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