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  • The following terms were not found in MeSH: MOLM, MOLM-14.

Sterol 14-Demethylase

An NADPH-dependent P450 enzyme that plays an essential role in the sterol biosynthetic pathway by catalyzing the demethylation of 14-methyl sterols such as lanosterol. The enzyme acts via the repeated hydroxylation of the 14-methyl group, resulting in its stepwise conversion into an alcohol, an aldehyde and then a carboxylate, which is removed as formic acid. Sterol 14-demethylase is an unusual cytochrome P450 enzyme in that it is found in a broad variety of organisms including ANIMALS; PLANTS; FUNGI; and protozoa.

Year introduced: 2011


14-3-3 Proteins

A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.

Year introduced: 2005(1981)


8,11,14-Eicosatrienoic Acid

A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5.

Year introduced: 1991(1975)


14-alpha Demethylase Inhibitors

Compounds that specifically inhibit STEROL 14-DEMETHYLASE. A variety of azole-derived ANTIFUNGAL AGENTS act through this mechanism.

Year introduced: 2011



A type I keratin that is found associated with the KERATIN-5 in the internal stratified EPITHELIUM. Mutations in the gene for keratin-14 are associated with EPIDERMOLYSIS BULLOSA SIMPLEX.

Year introduced: 2007(1998)


Matrix Metalloproteinase 14

A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.

Year introduced: 2007(1994)


Tumor Necrosis Factor Ligand Superfamily Member 14

A member of tumor necrosis factor superfamily found on activated LYMPHOCYTES and MONOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to LYMPHOTOXIN BETA RECEPTOR and TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 14.

Year introduced: 2007(1998)


Receptors, Tumor Necrosis Factor, Member 14

A novel member of the tumor-necrosis factor receptor family that can also mediate HERPES SIMPLEX VIRUS TYPE 1 entry into cells. It has specificity for TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 14 and the homotrimeric form of LYMPHOTOXIN-ALPHA. The receptor is abundantly expressed on T-LYMPHOCYTES and may play a role in regulating lymphocyte activation. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

Year introduced: 2007(1997)


Caspase 14

A short pro-domain caspase that is almost exclusively expressed in the EPIDERMIS and may play a role in the differentiation of epidermal KERATINOCYTES.

Year introduced: 2007(1998)


Mitogen-Activated Protein Kinase 14

A 38-kDa mitogen-activated protein kinase that is abundantly expressed in a broad variety of cell types. It is involved in the regulation of cellular stress responses as well as the control of proliferation and survival of many cell types. The kinase activity of the enzyme is inhibited by the pyridinyl-imidazole compound SB 203580.

Year introduced: 2005(1994)


12-Hydroxy-5,8,10,14-eicosatetraenoic Acid

A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)

Year introduced: 1997


5,8,11,14-Eicosatetraynoic Acid

A 20-carbon unsaturated fatty acid containing 4 alkyne bonds. It inhibits the enzymatic conversion of arachidonic acid to prostaglandins E(2) and F(2a).

Year introduced: 1991(1975)


Chromosomes, Human, Pair 14

A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.

Year introduced: 1987


delta(14)-sterol reductase [Supplementary Concept]

NADPH-dependent enzyme that catalyzes the formal trans addition of hydrogen across the 14,15-pi bond in 8,14-sterol dienes; forms 4,4-dimethylzymosterol in lanosterol metabolism pathway from 4,4-dimethyl-5alpha-cholesta-8,14,25-trien-3beta-ol or from 4,4-dimethyl-cholesta-8,14,24-trienol

Date introduced: January 1, 1979


bombesin (6-14)-NH2, Phe(6)-Cpa(14)-psi(13-14)- [Supplementary Concept]

a gastrin-releasing peptide receptor antagonist

Date introduced: March 4, 1993


bombesin (6-14), Nal(6)-Psi(13,14)-Phe(14)- [Supplementary Concept]

inhibits growth of small cell lung cancer

Date introduced: April 19, 1991


perfluorotetradecanoic acid [Supplementary Concept]

Date introduced: November 23, 2021


bombesin (6-14), Phe(6)-Leu(13)-psi(CH2NH)-Leu(14)- [Supplementary Concept]

bombesin receptor antagonist

Date introduced: March 6, 1995


11,12-dihydroxy-13,14-epoxy-11,12,13,14-tetrahydrodibenzo(a,l)pyrene [Supplementary Concept]

RN refers to (alpha,beta,beta,beta)-stereoisomer; structure in first source

Date introduced: July 5, 1994

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