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MCF-7 Cells
An estrogen responsive cell line derived from a patient with metastatic human breast ADENOCARCINOMA (at the Michigan Cancer Foundation.)
Year introduced: 2013
NL-608 [Supplementary Concept]
a nutlin 3 analog that induces apoptosis in human breast cancer MCF-7 cells
Date introduced: February 21, 2013
aspartyl-methionyl-prolyl-glycyl-threonyl-valyl-leucyl-proline [Supplementary Concept]
an MCF-7 cancer cell-binding peptide
Date introduced: February 23, 2012
Hyul-Tong-Ryung [Supplementary Concept]
commercially available mixure of 12 different Chinese plants, listed in first source; inhibits PMA-induced cellular invasion of MCF-7 human breast carcinoma cells
Date introduced: March 8, 2011
lapiferin [Supplementary Concept]
from Ferula vesceritensis, induces apoptosis pathway in MCF-7 breast cancer cells; structure in first source
Date introduced: May 4, 2010
terricollene A [Supplementary Concept]
from the endolichenic fungus Neurospora terricola; showed modest cytotoxicity against the human tumor cell lines HeLa and MCF-7; structure in first source
Date introduced: November 24, 2009
amamistatin A [Supplementary Concept]
showed antitumor activity against MCF-7 and PC-3 human tumor cells; structure in first source
Date introduced: June 7, 2007
amamistatin B [Supplementary Concept]
dohevanil [Supplementary Concept]
induces apoptosis in MCF-7 cells; structure in first source
Date introduced: April 12, 2006
chlorambucil-N-(2-(4-(4-bis(2-chloroethyl)aminophenyl)butyryl)aminoethyl)-5-(4-amidinophenyl)-2-furancarboxamide hydrochloride [Supplementary Concept]
an analogue of chlorambucil is a stronger inhibitor of protein and DNA synthesis in MCF-7 cells than is the parent drug
Date introduced: June 13, 2005
MACROD1 protein, human [Supplementary Concept]
is a gene cloned from lymphocytic cells, and its function is not known. The expression level of LRP16 mRNA was up-regulated by estrogen in breast cancer MCF-7 cells based on the computed aided serial analysis of gene expression (SAGE) analysis; RefSeq NM_014067
Date introduced: September 2, 2003
octreotide-conjugated paclitaxel [Supplementary Concept]
created by coupling taxol-succinate to the amino-terminal end of octreotide which retains the biological activity of taxol in inducing formation of tubulin bundles, eventually causing apoptosis of MCF-7 cells; structure in first source
Date introduced: August 31, 2000
Ber-EP4 monoclonal antibody [Supplementary Concept]
a commercially-available MAb generated by immunizing mice with cells from the MCF-7 breast carcinoma cell line; distinguishes epithelial mesothelioma from adenocarcinoma
Date introduced: March 19, 1999
RU 58668 [Supplementary Concept]
a steroidal antiestrogen; induces a long-term regression of human mammary MCF-7 tumors implanted in nude mice; structure given in first source
Date introduced: April 29, 1994
7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridine [Supplementary Concept]
inibits growth of B16 melanoma & MCF-7 mammary carcinoma cells
Date introduced: July 27, 1993
ZK 119010 [Supplementary Concept]
possess both antagonistic and agonistic potencies in MCF-7 cells
Date introduced: December 11, 1991
RU 39411 [Supplementary Concept]
inhibits tamoxifen-stimulated growth of an MCF-7 tumor variant; structure given in first source
Date introduced: August 23, 1989
LOC377776 protein, human [Supplementary Concept]
MW 24K estrogen-associated protein from endometrium; may serve as marker for endometrial development; srp27 was first described as an estrogen-induced 24K protein in MCF-7 cells; present in both normal stroma & stromal sarcoma
Date introduced: June 5, 1986
estrogen regulated protein [Supplementary Concept]
human proteins are from the MCF-7 breast tumor cell line; see also records for estrogen regulated proteins TTF1 protein, human and HSPB1 protein, human
Date introduced: September 7, 1983
LYF-11 [Supplementary Concept]
inhibits JAK2-STAT3 signaling pathway in MCF-7 cells
Date introduced: May 18, 2018