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MAP Kinase Signaling System

An intracellular signaling system involving the mitogen-activated protein kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.

Year introduced: 2000

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Tree Number(s): G02.111.820.560, G03.493.560, G04.835.560

MeSH Unique ID: D020935

Entry Terms:

  • MAP Kinase Cascade
  • Cascade, MAP Kinase
  • Kinase Cascade, MAP
  • MAP Kinase Cascades
  • MAP Kinase Modules
  • Module, MAP Kinase
  • MAP Kinase Signaling Cascades
  • MAP Kinase Module
  • MAP Kinase Signaling Cascade
  • MAP Kinase Signaling Pathways
  • MAP Kinase Signaling Pathway
  • ERK1-2 Pathway
  • ERK1 2 Pathway
  • ERK1-2 Pathways
  • Pathway, ERK1-2
  • Pathways, ERK1-2
  • ERK1 and ERK2 Pathway
  • ERK Signal Tranduction Pathway
  • ERK Pathway
  • ERK Pathways
  • Pathway, ERK
  • Pathways, ERK
  • MEK-ERK Pathway
  • MEK ERK Pathway
  • MEK-ERK Pathways
  • Pathway, MEK-ERK
  • Pathways, MEK-ERK
  • JNK Pathway
  • JNK Pathways
  • Pathway, JNK
  • Pathways, JNK
  • JNK Signaling Pathway
  • JNK Signaling Pathways
  • Pathway, JNK Signaling
  • Pathways, JNK Signaling
  • Signaling Pathway, JNK
  • Signaling Pathways, JNK
  • p38 Kinase Pathway
  • Kinase Pathway, p38
  • Kinase Pathways, p38
  • p38 Kinase Pathways
  • Pathway, p38 Kinase
  • Pathways, p38 Kinase
  • p38 Kinase Signaling Pathway

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