Format
Items per page

Send to:

Choose Destination

Search results

Items: 1 to 20 of 337

1.

Leukemia

A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

2.

Myeloid Cell Leukemia Sequence 1 Protein

A member of the myeloid leukemia factor (MLF) protein family with multiple alternatively spliced transcript variants encoding different protein isoforms. In hematopoietic cells, it is located mainly in the nucleus, and in non-hematopoietic cells, primarily in the cytoplasm with a punctate nuclear localization. MLF1 plays a role in cell cycle differentiation.

Year introduced: 2014

3.

Xenotropic murine leukemia virus-related virus

An endogenous GAMMARETROVIRUS from the germ line of mice but isolated from humans. It has close similarity to xenotropic MURINE LEUKEMIA VIRUS.

Year introduced: 2011

4.

Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative

A myelodysplastic/myeloproliferative disorder characterized by myelodysplasia associated with bone marrow and peripheral blood patterns similar to CHRONIC MYELOID LEUKEMIA, but cytogenetically lacking a PHILADELPHIA CHROMOSOME or bcr/abl fusion gene (GENES, ABL).

Year introduced: 2008

5.

Leukemia, Myelomonocytic, Juvenile

A leukemia affecting young children characterized by SPLENOMEGALY, enlarged lymph nodes, rashes, and hemorrhages. Traditionally classed as a myeloproliferative disease, it is now considered a mixed myeloproliferative-mylelodysplastic disorder.

Year introduced: 2008

6.

Leukemia, Prolymphocytic, B-Cell

A neoplasm of prolymphocytes affecting the blood, bone marrow, and spleen. It is characterized by prolymphocytes exceeding 55% of the lymphoid cells in the blood and profound splenomegaly.

Year introduced: 2008

7.

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

A leukemia/lymphoma found predominately in children and young adults and characterized LYMPHADENOPATHY and THYMUS GLAND involvement. It most frequently presents as a lymphoma, but a leukemic progression in the bone marrow is common.

Year introduced: 2008

8.

Precursor Cell Lymphoblastic Leukemia-Lymphoma

A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.

Year introduced: 2008

9.

Leukemia, Large Granular Lymphocytic

A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.

Year introduced: 2008

10.

Leukemia Inhibitory Factor Receptor alpha Subunit

A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.

Year introduced: 2007

11.

Leukemia Inhibitory Factor

An INTERLEUKIN-6 related cytokine that exhibits pleiotrophic effects on many physiological systems that involve cell proliferation, differentiation, and survival. Leukemia inhibitory factor binds to and acts through the lif receptor.

Year introduced: 2007(1980)

12.

Myeloid-Lymphoid Leukemia Protein

Myeloid-lymphoid leukemia protein is a transcription factor that maintains high levels of HOMEOTIC GENE expression during development. The GENE for myeloid-lymphoid leukemia protein is commonly disrupted in LEUKEMIA and combines with over 40 partner genes to form FUSION ONCOGENE PROTEINS.

Year introduced: 2006(1992)

13.

Graft vs Leukemia Effect

Immunological rejection of leukemia cells following bone marrow transplantation.

Year introduced: 2000

14.

Leukemia Virus, Gibbon Ape

A species of GAMMARETROVIRUS causing leukemia in the gibbon ape. Natural transmission is by contact.

Year introduced: 1994

15.

Radiation Leukemia Virus

A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) isolated from radiation-induced lymphomas in C57BL mice. It is leukemogenic, thymotrophic, can be transmitted vertically, and replicates only in vivo.

Year introduced: 1992

16.

Leukemia, Feline

A neoplastic disease of cats frequently associated with feline leukemia virus infection.

Year introduced: 1992

17.

Leukemia, Myelomonocytic, Acute

A pediatric acute myeloid leukemia involving both myeloid and monocytoid precursors. At least 20% of non-erythroid cells are of monocytic origin.

Year introduced: 1989

18.

Leukemia, Myelomonocytic, Chronic

A myelodysplastic-myeloproliferative disease characterized by monocytosis, increased monocytes in the bone marrow, variable degrees of dysplasia, but an absence of immature granulocytes in the blood.

Year introduced: 1989

19.

Leukemia, Promyelocytic, Acute

An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.

Year introduced: 1989

20.

Leukemia, Eosinophilic, Acute

A rare acute myeloid leukemia characterized by abnormal EOSINOPHILS in the bone marrow.

Year introduced: 1989

Format
Items per page

Send to:

Choose Destination

Supplemental Content

Loading ...
Support Center