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HeLa Cells
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays.
Year introduced: 2011 (1965)
KB Cells
This line KB is now known to be a subline of the ubiquitous KERATIN-forming tumor cell line HeLa. It was originally thought to be derived from an epidermal carcinoma of the mouth, but was subsequently found, based on isoenzyme analysis, HeLa marker chromosomes, and DNA fingerprinting, to have been established via contamination by HELA CELLS. The cells are positive for keratin by immunoperoxidase staining. KB cells have been reported to contain human papillomavirus18 (HPV-18) sequences.
Year introduced: 1985
TCEAL1 protein, human [Supplementary Concept]
RefSeq NM_004780
Date introduced: July 8, 1994
cytoplasmic linker protein 170 [Supplementary Concept]
amino acid sequence given in first source; a marker for REED-STERNBERG CELLS of HODGKIN DISEASE; restin may suppress the growth of tumor in vivo; CLIP-170 links endocytic vesicles to microtubules; homologous to DP-150 (rat), Glued (Drosophila) & BIK1 (yeast); from HeLa cells; do not confuse with APR-1, a pheromone-binding protein; RefSeq NM_014061 (MAGEH1, human), NM_198240 (RSN, human), NM_019765 (mouse), NM_031745 (rat)
Date introduced: October 16, 1992
APS-1d compound [Supplementary Concept]
from Angelica sinensis, induces the apoptosis of cervical cancer HeLa cells through an intrinsic apoptotic pathway
Date introduced: December 2, 2010
terricollene A [Supplementary Concept]
from the endolichenic fungus Neurospora terricola; showed modest cytotoxicity against the human tumor cell lines HeLa and MCF-7; structure in first source
Date introduced: November 24, 2009
3,4-dihydro-3,4,7,9,12-pentahydroxy-2,2-dimethyl-2H,6H-pyrano(3,2-b)xanthen-6-one [Supplementary Concept]
from Garcinia lancilimba showing apoptotic effects against HeLa-C3 cells; structure in first source
Date introduced: February 4, 2009
1,3,5-trihydroxy-6-methoxy-7-(3-methylbut-2-enyl)xanthone [Supplementary Concept]
1,3-dihydroxy-5,6-dimethoxy-7-(3-methylbut-2-enyl)xanthone [Supplementary Concept]
p-hydroxymethoxybenzobijuglone [Supplementary Concept]
a cytotoxic compound from Juglans mandshurica leaves that induced apoptosis in HeLa cervical cancer cells; structure in first source
Date introduced: February 6, 2008
JBIR-02 compound [Supplementary Concept]
inhibits nuclear export of beta-arrestin in HeLa cells; isolated from Streptomyces; structure in first source
Date introduced: November 19, 2007
SNL glycoprotein, Solanum nigrum [Supplementary Concept]
150 kDa protein with carbohydrate (69.74%) and protein content (30.26%) that exhibits inhibitory effect on HeLa cells via apoptosis, and may be a potential candidate in field of anticancer drug discovery
Date introduced: July 13, 2007
ACTX-8 protein, Agkistrodon acutus [Supplementary Concept]
a cytotoxic protein from Agkistrodon acutus snake venom that induces apoptosis in Hela cervical cancer cells
Date introduced: March 28, 2007
USP36 protein, human [Supplementary Concept]
RefSeq NM_025090
Date introduced: June 12, 2005
Erc protein, human [Supplementary Concept]
expressed in renal carcinoma (Erc); homologue of Erc gene was detected in human cell lines HeLa (cervical carcinoma) and O-3(renal cell carcinoma); predicted amino acid sequence in first source
Date introduced: September 19, 2000
MNBP-1 protein, human [Supplementary Concept]
isolated from nuclear extracts of HeLa and Ltk(-) cells; recognizes long terminal repeat and contains a distal negative regulatory element within the mouse mammary tumor virus; amino acid sequence in first source
Date introduced: December 1, 1999
cruciform-specific DNA-binding protein, human [Supplementary Concept]
66 kDa protein isolated from HeLa cell nuclei; member of 14-3-3 protein family; contains beta, gamma, epsilon, zeta, and sigma isoforms of 14-3-3 family members; amino acid sequence in first source
Date introduced: November 2, 1998
HelD protein, Rhodobacter capsulatus [Supplementary Concept]
required for cytochrome c biogenesis; forms complex with HelA, HelB, and HelC; amino acid sequence in first source; do not confuse with helicase IV; GenBank M96013
Date introduced: June 1, 1998
HelC protein, bacteria [Supplementary Concept]
required for cytochrome c biogenesis in some bacteria; forms complex with HelA, HelB, and HelD; amino acid sequence in first source
HelB protein, Rhodobacter capsulatus [Supplementary Concept]
required for cytochrome c biogenesis; conserved in gram negative bacteria; forms complex with HelA, HelC, and HelD; amino acid sequence in first source