Items per page

Send to:

Choose Destination

Search results

Items: 1 to 20 of 31



Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)


Optic Nerve Glioma

Glial cell derived tumors arising from the optic nerve, usually presenting in childhood.

Year introduced: 2000


Glioma, Subependymal

Rare, slow-growing, benign intraventricular tumors, often asymptomatic and discovered incidentally. The tumors are classified histologically as ependymomas and demonstrate a proliferation of subependymal fibrillary astrocytes among the ependymal tumor cells. (From Clin Neurol Neurosurg 1997 Feb;99(1):17-22)

Year introduced: 1994


Zinc Finger Protein GLI1

A transcriptional activator and oncogene protein that contains two CYS2-HIS2 ZINC FINGERS. Two isoforms are expressed; both regulate the expression of specific genes during development of craniofacial features, digits, the CENTRAL NERVOUS SYSTEM; and the GASTROINTESTINAL TRACT. They also regulate SONIC HEDGEHOG PROTEIN signaling and cell proliferation.

Year introduced: 2017 (1993)


Vascular Endothelial Growth Factor A

The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.

Year introduced: 2004



Rare mixed tumors of the brain and rarely the spinal cord which contain malignant neuroectodermal (glial) and mesenchymal components, including spindle-shaped fibrosarcoma cells. These tumors are highly aggressive and present primarily in adults as rapidly expanding mass lesions. They may arise in tissue that has been previously irradiated. (From Br J Neurosurg 1995 Apr;9(2):171-8)

Year introduced: 1994



A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)



Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)

Year introduced: 1963


LGI1 protein, human [Supplementary Concept]

RefSeq NM_005097

Date introduced: January 15, 1999


LRRN2 protein, human [Supplementary Concept]

RefSeq NM_006338

Date introduced: July 31, 1998


GLIPR1 protein, human [Supplementary Concept]

RefSeq NM_006851

Date introduced: August 11, 1995


glioma-derived monocyte chemotactic factor 2 [Supplementary Concept]

76 amino acid residues given in first source; attracts human monocytes but not neutrophils; mediator of cellular immune reactions

Date introduced: April 27, 1989


Zinc Finger Protein Gli3

A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.

Year introduced: 2018


Lgi1b protein, zebrafish [Supplementary Concept]

RefSeq NM_001128769

Date introduced: February 23, 2012


Glioma of Brain, Familial [Supplementary Concept]

Date introduced: November 5, 2012


Lgi1a protein, zebrafish [Supplementary Concept]

GenBank BC056753

Date introduced: February 16, 2011


Glipr1l1 protein, mouse [Supplementary Concept]

RefSeq NM_027018

Date introduced: June 6, 2010


LGI3 protein, rat [Supplementary Concept]

GenBank XM224337

Date introduced: October 26, 2007


GLIPR-2 protein, mouse [Supplementary Concept]

GenBank AK017557

Date introduced: May 25, 2007


LGI3 protein, mouse [Supplementary Concept]

GenBank AF515590

Date introduced: June 21, 2006

Items per page

Send to:

Choose Destination

Supplemental Content

Loading ...
Support Center