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A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.

Year introduced: 1994


Transforming Growth Factor beta2

A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.

Year introduced: 2007(2000)



A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)



Rare mixed tumors of the brain and rarely the spinal cord which contain malignant neuroectodermal (glial) and mesenchymal components, including spindle-shaped fibrosarcoma cells. These tumors are highly aggressive and present primarily in adults as rapidly expanding mass lesions. They may arise in tissue that has been previously irradiated. (From Br J Neurosurg 1995 Apr;9(2):171-8)

Year introduced: 1994


Trim8 protein, mouse [Supplementary Concept]

a member of the RBCC subfamily of RING finger proteins; RefSeq NM_053100

Date introduced: August 6, 2004


GOPC protein, human [Supplementary Concept]

RefSeq NM_020399

Date introduced: September 11, 2001


TRIM8 protein, human [Supplementary Concept]

RefSeq NM_030912

Date introduced: January 23, 2001


NIPSNAP2 protein, human [Supplementary Concept]

RefSeq NM_001483

Date introduced: July 31, 1998


oncofetal antigens [Supplementary Concept]

see also record for pancreas-specific antigen & pancreas cancer-associated antigen, which is different from oncofetal antigens

Date introduced: August 27, 1981

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