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An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

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Tree Number(s): D03.633.100.733.631.192.500

MeSH Unique ID: D008727

Registry Number: YL5FZ2Y5U1

Entry Terms:

  • Amethopterin
  • Mexate
  • Methotrexate Hydrate
  • Hydrate, Methotrexate
  • Methotrexate Sodium
  • Sodium, Methotrexate
  • Methotrexate, Sodium Salt
  • Methotrexate, Disodium Salt
  • Methotrexate, (D)-Isomer
  • Methotrexate, (DL)-Isomer
  • Methotrexate, Dicesium Salt
  • Dicesium Salt Methotrexate

Pharmacologic Action:

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