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A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

Year introduced: 1987(1981)

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Tree Number(s): D02.455.426.559.847.638.960.675.250, D04.615.638.960.675.250, D09.408.348.275

MeSH Unique ID: D005047

Registry Number: 6PLQ3CP4P3

Entry Terms:

  • Demethyl Epipodophyllotoxin Ethylidine Glucoside
  • Eposide
  • Vepesid
  • Etoposide, alpha-D-Glucopyranosyl Isomer
  • alpha-D-Glucopyranosyl Isomer Etoposide
  • Etoposide, alpha D Glucopyranosyl Isomer
  • Etoposide, (5S)-Isomer
  • Etoposide, (5a alpha)-Isomer
  • Etoposide, (5a alpha,9 alpha)-Isomer
  • NSC-141540
  • NSC141540
  • NSC 141540
  • VP 16-213
  • VP 16213
  • VP 16 213
  • VP-16
  • VP16
  • VP 16
  • Celltop
  • Eposin
  • Toposar
  • Etoposide Teva
  • Teva, Etoposide
  • Eto-GRY
  • Eto GRY
  • Etoposide Pierre Fabre
  • Etoposido Ferrer Farma
  • Etopos
  • Exitop
  • Lastet
  • Onkoposid
  • Riboposid
  • Vépéside-Sandoz
  • Vépéside Sandoz
  • Etomedac

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