U.S. flag

An official website of the United States government


Send to:

Choose Destination

Depressive Disorder, Major

Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)

Year introduced: 1981

PubMed search builder options


Tree Number(s): F03.600.300.375

MeSH Unique ID: D003865

Entry Terms:

  • Depressive Disorders, Major
  • Major Depressive Disorders
  • Major Depressive Disorder
  • Depression, Involutional
  • Involutional Depression
  • Melancholia, Involutional
  • Involutional Melancholia
  • Psychosis, Involutional
  • Involutional Psychoses
  • Involutional Psychosis
  • Psychoses, Involutional
  • Paraphrenia, Involutional
  • Involutional Paraphrenia
  • Involutional Paraphrenias
  • Paraphrenias, Involutional

Supplemental Content

Loading ...