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A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

Year introduced: 1966

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Tree Number(s): D03.633.300.200, D04.345.566.252, D12.644.641.252

MeSH Unique ID: D003609

Registry Number: 1CC1JFE158

Entry Terms:

  • Actinomycin D
  • Meractinomycin
  • Actinomycin
  • Cosmegen
  • Lyovac-Cosmegen
  • LyovacCosmegen
  • Lyovac Cosmegen
  • Cosmegen Lyovac
  • Lyovac, Cosmegen

Pharmacologic Action:

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