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An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.

Year introduced: COCAINE DERIVATIVES was see under COCAINE 1975-1977

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Tree Number(s): D02.145.074.722.388, D03.132.889.354, D03.605.084.500.722.388, D03.605.869.388

MeSH Unique ID: D003042

Registry Number: I5Y540LHVR

Entry Terms:

  • Cocaine Hydrochloride
  • Hydrochloride, Cocaine
  • Cocaine HCl
  • HCl, Cocaine

Pharmacologic Action:

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