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Global Burden of Disease

Measure of the burden of disease using the disability-adjusted-life-year (DALY). This time-based measure combines years of life lost due to premature mortality and years of life lost due to time lived in states of less than full health. The metric was developed to assess the burden of disease consistently across diseases, risk factors and regions.

Year introduced: 2017


Tumor Burden

The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.

Year introduced: 2005


Body Burden

The total amount of a chemical, metal or radioactive substance present at any time after absorption in the body of man or animal.

Year introduced: 1973(1971)


Cost of Illness

The personal cost of disease which may be economic, social, or psychological. The cost of illness may be reflected in absenteeism, productivity, response to treatment, peace of mind, or QUALITY OF LIFE. It differs from HEALTH CARE COSTS, the societal cost of providing services related to the delivery of health care.

Year introduced: 1993


Viral Load

The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.

Year introduced: 1997


Dependency (Psychology)

The tendency of an individual or individuals to rely on others for advice, guidance, or support.

Year introduced: 1991(1975)


Teach-Back Communication

Providing the patient, family or others information, and then allowing them to take an action or restate the information in their own words. The clinician prefaces communications with a statement framed to show the clinician has the burden of effective communication rather than the patient.

Year introduced: 2014


National Institute of Environmental Health Sciences (U.S.)

Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic and applied research to reduce the burden of human illness and dysfunction from environmental causes by, defining how environmental exposures, genetic susceptibility, and age interact to affect an individual's health. It was established in 1969.

Year introduced: 2008


H11 protein, Haemonchus contortus [Supplementary Concept]

an Aminopeptidase N; major microvillar integral membrane protein of the Haemonchus intestine; vaccination of merino lambs with extracts of adult H. contortus enriched with H11 caused a reduction of 88% in total worm burden at post-mortem 35 days post-challenge; has been sequenced

Date introduced: May 24, 1993


Mass Drug Administration

Administration of a medication to at-risk individuals in a population without individual diagnosis. It is often used in order to treat, control, and/or prevent spread of often endemic DISEASE OUTBREAKS such as NEGLECTED DISEASES in high disease burden areas.

Year introduced: 2018


In Vivo Dosimetry

A procedure to measure the amount of radiation absorbed by the body during RADIOTHERAPY by DOSIMETERS in the patient’s skin or natural cavities.

Year introduced: 2017


CPH4-136 compound [Supplementary Concept]

antiprotozoal; moderately reduces Toxoplasma gondii cyst burden in infected mice

Date introduced: October 21, 2014


SDPM1 peptide [Supplementary Concept]

an engineered non-native Aβ amyloid-specific binding peptide, lowers brain Aβ amyloid plaque burden and brain Aβ1–40 and Aβ1–42 peptide levels, improves cognitive learning and memory

Date introduced: September 2, 2014

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