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Items: 14

1.

Leukemia, Myeloid, Acute

Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.

Year introduced: 2008 (1989)

2.

Core Binding Factor Alpha 2 Subunit

A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.

Year introduced: 2006(1993)

3.
4.

Acute erythroleukemia [Supplementary Concept]

A leukemic or pre-leukemic condition characterized by acute erythroblastic leukemia. Patients may also have elevated IgM and erythrocyte hexokinase levels, as well as marrow hypocellularity and chromosome abnormalities. Familial cases may be associated with mutations in the the EPOR gene. OMIM: 133180

Date introduced: June 25, 2010

5.

Core Binding Factor Alpha 3 Subunit

A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain.

Year introduced: 2006(2001)

6.

Core Binding Factor Alpha 1 Subunit

A transcription factor that dimerizes with CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain and is involved in genetic regulation of skeletal development and CELL DIFFERENTIATION.

Year introduced: 2006(1997)

7.

Core Binding Factor alpha Subunits

A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.

Year introduced: 2006(1987)

8.

Leukemia, Monocytic, Acute

An acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes, and MONOCYTES.

Year introduced: 1989

9.

Runx3 protein, mouse [Supplementary Concept]

RefSeq NM_019732

Date introduced: July 29, 2005

10.

Runx3 protein, human [Supplementary Concept]

RefSeq NM_004350

Date introduced: July 29, 2005

11.

RUNX1 protein, human [Supplementary Concept]

RefSeq NM_001001890

Date introduced: July 29, 2005

12.

Runx1 protein, rat [Supplementary Concept]

RefSeq NM_017325

Date introduced: July 29, 2005

13.

Runx1 protein, mouse [Supplementary Concept]

RefSeq NM_009821

Date introduced: July 29, 2005

14.

GATA2 Deficiency

A rare disorder of the immune system with wide-ranging effects which include GATA2 Transcription Factor dysfunction, immunodeficiency, myelodysplastic syndrome (ineffective blood cell production), lung disease, and problems of the vascular and lymphatic system.

Year introduced: 2019

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