Protein Footprinting

A method for determining points of contact between interacting proteins or binding sites of proteins to nucleic acids. Protein footprinting utilizes a protein cutting reagent or protease. Protein cleavage is inhibited where the proteins, or nucleic acids and protein, contact each other. After completion of the cutting reaction, the remaining peptide fragments are analyzed by electrophoresis.

Year introduced: 2001

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Tree Number(s): E05.196.700.690, E05.393.760.705.685.690

MeSH Unique ID: D023302

Entry Terms:

• Footprinting, Protein
• Protein Footprints
• Footprint, Protein
• Protein Footprint
• Footprints, Protein

All MeSH Categories
Analytical, Diagnostic and Therapeutic Techniques and Equipment Category
Investigative Techniques
Chemistry Techniques, Analytical
Peptide Mapping
Protein Footprinting

All MeSH Categories
Analytical, Diagnostic and Therapeutic Techniques and Equipment Category
Investigative Techniques
Genetic Techniques
Sequence Analysis
Sequence Analysis, Protein
Peptide Mapping
Protein Footprinting