Hemidesmosomes

An anchoring junction of the cell to a non-cellular substrate, similar in morphology to halves of DESMOSOMES. They are composed of specialized areas of the plasma membrane where INTERMEDIATE FILAMENTS bind on the cytoplasmic face to the transmembrane linkers, INTEGRINS, via intracellular attachment proteins, while the extracellular domain of the integrins binds to EXTRACELLULAR MATRIX PROTEINS.

Year introduced: 2001

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Tree Number(s): A11.284.149.165.165.360

MeSH Unique ID: D022002

Entry Terms:

• Hemidesmosome

Previous Indexing:

• Desmosomes (1972-2000)

All MeSH Categories
Anatomy Category
Cells
Cellular Structures
Cell Membrane
Cell Membrane Structures
Cell-Matrix Junctions
Hemidesmosomes