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Isaacs Syndrome

A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)

Year introduced: 2000

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Tree Number(s): C05.651.392, C10.668.829.425

MeSH Unique ID: D020386

Entry Terms:

  • Gamstorp-Wohlfart Syndrome
  • Gamstorp Wohlfart Syndrome
  • Gamstorp-Wohlfart Syndromes
  • Syndromes, Gamstorp-Wohlfart
  • Isaacs' Syndrome
  • Isaac Syndrome
  • Isaacs-Mertens Syndrome
  • Isaacs Mertens Syndrome
  • Syndromes, Isaacs-Mertens
  • Myokymia, Myotonia, Muscle Wasting, And Hyperhidrosis
  • Neuromyotonia
  • Pseudomyotonia
  • Pseudomyotonia Syndrome of Isaacs
  • Isaacs Pseudomyotonia Syndrome
  • Quantal Squander
  • Syndrome of Continuous Muscle Activity
  • Continuous Muscle Activity Syndrome
  • Myokymia, Continuous
  • Continuous Myokymia
  • Continuous Myokymias
  • Myokymias, Continuous
  • Acquired Neuromyotonia
  • Neuromyotonia, Acquired

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