Nonsuppressible Insulin-Like Activity

A blood protein (NSILA) which mimics the biological activity of insulin in serum, but is not suppressed by insulin antibodies. During acid-ethanol extraction of Cohn fraction III, 10% of the activity is found in the supernatant (NSILA-S) and the remaining activity in the precipitate (NSILA-P). The latter is a large molecular compound, much less stable than the soluble fraction. NSILA-S is a more potent growth factor than insulin and exhibits sulfation activity.

Year introduced: 1977

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Tree Number(s): D12.776.124.862.575

MeSH Unique ID: D009632

Entry Terms:

• Activity, Nonsuppressible Insulin-Like
• Insulin-Like Activity, Nonsuppressible
• Nonsuppressible Insulin Like Activity
• Nonsuppressible Insulinlike Activity
• Activity, Nonsuppressible Insulinlike
• Insulinlike Activity, Nonsuppressible
• NSILA
• NSILA-P
• NSILA-S

Previous Indexing:

• Blood Proteins (1966-1976)
• Insulin (1966-1976)

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Blood Proteins
Somatomedins
Nonsuppressible Insulin-Like Activity