beta-N-Acetylhexosaminidases

A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.

Year introduced: 2008(1988)

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Tree Number(s): D08.811.277.450.483.180

MeSH Unique ID: D001619

Registry Number: EC 3.2.1.52

Entry Terms:

• beta N Acetylhexosaminidases
• N-Acetyl-beta-D-hexosaminidase
• N Acetyl beta D hexosaminidase
• beta-Hexosaminidase
• beta Hexosaminidase
• beta-N-Acetyl-D-hexosaminidase
• beta N Acetyl D hexosaminidase
• beta-N-Acetyl-hexosaminidase
• beta N Acetyl hexosaminidase
• beta-N-Acetylhexosaminidase
• beta N Acetylhexosaminidase

Previous Indexing:

• Glycoside Hydrolases (1966-1970)
• Hexosaminidases (1971-1986)

See Also:

• Sandhoff Disease
• Tay-Sachs Disease

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Hydrolases
Glycoside Hydrolases
Hexosaminidases
beta-N-Acetylhexosaminidases
Acetylglucosaminidase
Hexosaminidase A
beta-Hexosaminidase alpha Chain
beta-Hexosaminidase beta Chain
Hexosaminidase B
beta-Hexosaminidase beta Chain